About BPaL
LIFT-TB focuses on speeding access to pretomanid-based regimens. World Health Organization guidelines allow for the programmatic treatment of most DR-TB with pretomanid-based regimens – either BPaL ( pretomanid +bedaquiline + linezolid), or BPaLM (BPaL + moxifloxacin). TB Alliance has studied the BPaL regimen in multiple clinical trials, including Nix-TB and ZeNix, which enrolled people with XDR-TB as well as treatment-intolerant or non-responsive MDR-TB. BPaL has been approved by 16 regulatory authorities, including the U.S. FDA and European Medicines Agency.
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Treatment of Highly Drug-Resistant Pulmonary Tuberculosis (NEJM) Download PDF
Final Results of the NIX-TB Clinical Study of the BPaL Regimen for Highly Resistant Tuberculosis (CROI 2021) Download PDF
Bedaquiline–Pretomanid–Linezolid Regimens for Drug-Resistant Tuberculosis Download PDF
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Budgetary impact of using BPaL for treating extensively drug-resistant tuberculosis (BMJ Global Health) Download PDF
Cost-effectiveness of bedaquiline, pretomanid and linezolid for treatment of extensively drug- resistant tuberculosis in South Africa, Georgia and the Philippines (BMJ Open) Download PDF
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Pretomanid Full Prescribing Information (U.S. FDA) Download PDF
WHO Rapid communication: Key changes to the treatment of drug-resistant tuberculosis (issued 2022) Download PDF
WHO consolidated guidelines on tuberculosis; Drug-resistant tuberculosis treatment (issued 2020) Download PDF
WHO operational handbook on tuberculosis; Drug-resistant tuberculosis treatment (issued 2020) Download PDF
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BPaL introduction and scale-up under operational research conditions - Generic Protocol (version 5) Download PDF
Clinical Guide for the Introduction of the BPaL Treatment Regimen (Philippines) Download PDF
BPaL Operational Research Exclusion and Inclusion Criteria (Philippines) Download PDF
Schedule of Baseline, Routine and Post-Treatment Monitoring Evaluations for the BPaL Operational Research (Philippines) Download PDF
Acceptable BPaL Regimen Modifications Under Operational Research (Philippines) Download PDF
Severity Grading Scales for Adverse Events of Special Interest in the BPaL Operational Research (Philippines) Download PDF
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Programmatic introduction of the BPaL regimen: A practical implementation guide Download PDF
LIFT-TB Implementation Plan (Philippines) Download PDF
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Projected use of pretomanid, bedaquiline and linezolid in all-oral regimens for multi-drug resistant tuberculosis from 2021-2025 (SSRN) Download PDF
Training of the Trainers: Training Kit
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Session Overview Download PDF
Rationale for BPaL Regimen Download PDF
Updates on PMDT and the Role of BPaL Regimen in the Philippines View Video
BPaL Operation Research Protocol (Philippines) Pt 1 Download PDF
BPaL Operation Research Protocol (Philippines) Pt 2 Download PDF
Implementing Structure for the Pilot Study to Test the Effectiveness and Safety of the Bedaquiline-Pretomanid-Linezolid (BPaL) Treatment Regimen in the Philippines Download PDF
Diagnostic Testing in the TB Laboratory Network Download PDF
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Session Overview Download PDF
Specimen Handling and Other TB Laboratory-Related Procedures Download PDF
Phenotypic DST Of BPaL And EQC Material For LPA Download PDF
Active TB Drug-Safety Monitoring and Management (aDSM) in the Philippines Download PDF
aDSM in the BPaL OR: Component Drugs in the BPaL Regimen Download PDF
Modification, Interruption and Discontinuation in BPaL Download PDF
aDSM Application - Clinical Monitoring of AESIs Download PDF
aDSM Application - Clinical Management of AESIs Download PDF
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Session Overview Download PDF
Case Studies on the BPaL Regimen Download PDF
Role of TBMAC in BPaL Research Download PDF
Support of ACCESS TB Project on PMDT & BPaL OR Download PDF
Guidance on BPaL OR Data Collection Download PDF
BPaL Data Management and REDCap Presentation Download PDF
BPaL Project Monitoring Download PDF
Reminders on Good Clinical Practice Download PDF
DST & LPA Training Materials
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Phenotypic Drug Susceptibility Testing for BPaL: MGIT without TBeXIST View video
Phenotypic Drug Susceptibility Testing for BPaL: MGIT without TBeXIST Download PPT
External QC for HAIN MTBDRsl View video
External QC for HAIN MTBDRsl Download PDF
Guidelines on Xpert MTB/XDR Download PDF
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Phenotypic Drug Susceptibility Testing for BPaL: MGIT without TBeXIST View video
Advocacy Training Materials
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Development of Training Materials for Advocates Download PPT
Magnitude of the DR-TB Problem Download PPT
Diagnosis of TB and DR-TB Download PPT
MDR-TB: Shorter and Longer Regimens Download PPT
BPaL Regimen Download PPT
BPaL Operational Research Download PPT
Patient Monitoring for Treatment Response Download PPT
Patient Monitoring for Drug Safety Download PPT
Videos
Videos on the launch, status, and impact of LIFT-TB